Enhancing hepatoprotective action: oxyberberine amorphous solid dispersion system targeting TLR4
Abstract Oxyberberine (OBB) is a significant natural compound, with excellent hepatoprotective properties.However, the poor water solubility of OBB hinders its release and absorption thus resulting in low bioavailability.To overcome these drawbacks of OBB, amorphous spray-dried powders (ASDs) of OBB were formulated.The dissolution, characterization